Gene information
Official symbol GHRL
Official full name ghrelin and obestatin prepropeptide
Gene type protein-coding gene
Chromosome3p25.3
Alias symbolMTLRP|ghrelin|obestatin
Gene familyNeuropeptides
Resources
Entrez Gene 51738
HGNC HGNC:18129
Ensembl ENSG00000157017
Vega OTTHUMG00000155360
UCSC uc021wsz.2
GO terms: 155 records
GO Description Category LogP Number of genes Detail
GO:0001501 skeletal system development GO Biological Processes -17.2073293 69 More
GO:0001664 G protein-coupled receptor binding GO Molecular Functions -22.7408810 35 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001890 placenta development GO Biological Processes -8.66149584 25 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0001938 positive regulation of endothelial cell proliferation GO Biological Processes -32.0012114 45 More
GO:0002793 positive regulation of peptide secretion GO Biological Processes -7.26567394 18 More
GO:0005179 hormone activity GO Molecular Functions -33.3562443 33 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0005975 carbohydrate metabolic process GO Biological Processes -4.30473825 38 More
GO:0006937 regulation of muscle contraction GO Biological Processes -20.8046481 43 More
GO:0006940 regulation of smooth muscle contraction GO Biological Processes -12.9613663 21 More
GO:0007204 positive regulation of cytosolic calcium ion concentration GO Biological Processes -15.6883547 39 More
GO:0007268 chemical synaptic transmission GO Biological Processes -4.44678751 35 More
GO:0007565 female pregnancy GO Biological Processes -18.4002911 25 More
GO:0007586 digestion GO Biological Processes -7.00342423 19 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0007631 feeding behavior GO Biological Processes -8.63374021 12 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009755 hormone-mediated signaling pathway GO Biological Processes -4.05849698 16 More
GO:0009914 hormone transport GO Biological Processes -6.35710158 16 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0016525 negative regulation of angiogenesis GO Biological Processes -31.9326641 51 More
GO:0022600 digestive system process GO Biological Processes -8.16734280 17 More
GO:0023061 signal release GO Biological Processes -5.50151396 21 More
GO:0030029 actin filament-based process GO Biological Processes -9.62516039 61 More
GO:0030036 actin cytoskeleton organization GO Biological Processes -5.67075265 47 More
GO:0030296 protein tyrosine kinase activator activity GO Molecular Functions -2.46582511 5 More
GO:0030424 axon GO Cellular Components -6.14132550 54 More
GO:0030534 adult behavior GO Biological Processes -6.59104580 21 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031175 neuron projection development GO Biological Processes -7.36986002 58 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0031644 regulation of nervous system process GO Biological Processes -8.22607591 24 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032024 positive regulation of insulin secretion GO Biological Processes -3.33317104 10 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032368 regulation of lipid transport GO Biological Processes -34.5766289 54 More
GO:0032651 regulation of interleukin-1 beta production GO Biological Processes -19.7300517 34 More
GO:0032652 regulation of interleukin-1 production GO Biological Processes -24.2088254 41 More
GO:0032675 regulation of interleukin-6 production GO Biological Processes -28.2553997 51 More
GO:0032680 regulation of tumor necrosis factor production GO Biological Processes -32.0729913 56 More
GO:0032691 negative regulation of interleukin-1 beta production GO Biological Processes -9.98402343 15 More
GO:0032692 negative regulation of interleukin-1 production GO Biological Processes -11.9554195 18 More
GO:0032720 negative regulation of tumor necrosis factor production GO Biological Processes -18.6356508 28 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0032940 secretion by cell GO Biological Processes -8.42144465 43 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0040013 negative regulation of locomotion GO Biological Processes -30.7871461 81 More
GO:0040014 regulation of multicellular organism growth GO Biological Processes -9.11971182 17 More
GO:0042391 regulation of membrane potential GO Biological Processes -15.0641346 59 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0044058 regulation of digestive system process GO Biological Processes -4.95295157 10 More
GO:0044060 regulation of endocrine process GO Biological Processes -7.84992769 12 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0044703 multi-organism reproductive process GO Biological Processes -20.5752550 28 More
GO:0044706 multi-multicellular organism process GO Biological Processes -20.0155761 28 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0045927 positive regulation of growth GO Biological Processes -20.3035639 52 More
GO:0045933 positive regulation of muscle contraction GO Biological Processes -10.2635447 16 More
GO:0045987 positive regulation of smooth muscle contraction GO Biological Processes -5.46031079 9 More
GO:0046879 hormone secretion GO Biological Processes -6.27678757 15 More
GO:0046887 positive regulation of hormone secretion GO Biological Processes -9.61661717 24 More
GO:0046903 secretion GO Biological Processes -18.5147167 70 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048521 negative regulation of behavior GO Biological Processes -4.88157794 4 More
GO:0048608 reproductive structure development GO Biological Processes -16.4007448 61 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0048639 positive regulation of developmental growth GO Biological Processes -14.4198804 35 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050679 positive regulation of epithelial cell proliferation GO Biological Processes -31.4834672 59 More
GO:0050680 negative regulation of epithelial cell proliferation GO Biological Processes -26.5961536 48 More
GO:0050708 regulation of protein secretion GO Biological Processes -30.3716714 63 More
GO:0050709 negative regulation of protein secretion GO Biological Processes -12.5236372 21 More
GO:0050714 positive regulation of protein secretion GO Biological Processes -15.7339081 32 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.9747849 34 More
GO:0050795 regulation of behavior GO Biological Processes -5.81792293 14 More
GO:0050803 regulation of synapse structure or activity GO Biological Processes -6.38009123 27 More
GO:0050804 modulation of chemical synaptic transmission GO Biological Processes -15.2260557 60 More
GO:0050807 regulation of synapse organization GO Biological Processes -6.08931613 26 More
GO:0050886 endocrine process GO Biological Processes -9.16554283 10 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051047 positive regulation of secretion GO Biological Processes -32.2282376 71 More
GO:0051048 negative regulation of secretion GO Biological Processes -20.2278199 42 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051222 positive regulation of protein transport GO Biological Processes -13.8994291 46 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0051224 negative regulation of protein transport GO Biological Processes -11.0190941 26 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051960 regulation of nervous system development GO Biological Processes -17.2202851 64 More
GO:0051962 positive regulation of nervous system development GO Biological Processes -13.2580156 43 More
GO:0051963 regulation of synapse assembly GO Biological Processes -2.88690436 12 More
GO:0051965 positive regulation of synapse assembly GO Biological Processes -1.78923844 7 More
GO:0060078 regulation of postsynaptic membrane potential GO Biological Processes -2.74505261 11 More
GO:0060135 maternal process involved in female pregnancy GO Biological Processes -5.36863544 12 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0060259 regulation of feeding behavior GO Biological Processes -4.62385244 5 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0061097 regulation of protein tyrosine kinase activity GO Biological Processes -4.69934335 14 More
GO:0061098 positive regulation of protein tyrosine kinase activity GO Biological Processes -4.90193440 11 More
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus GO Biological Processes -2.97443173 8 More
GO:0061458 reproductive system development GO Biological Processes -16.2516665 61 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:0090277 positive regulation of peptide hormone secretion GO Biological Processes -6.66447400 17 More
GO:0098685 Schaffer collateral - CA1 synapse GO Cellular Components -5.81792293 14 More
GO:0098916 anterograde trans-synaptic signaling GO Biological Processes -4.44678751 35 More
GO:0098978 glutamatergic synapse GO Cellular Components -4.83590061 31 More
GO:0099175 regulation of postsynapse organization GO Biological Processes -4.87425615 14 More
GO:0099177 regulation of trans-synaptic signaling GO Biological Processes -15.1793607 60 More
GO:0099536 synaptic signaling GO Biological Processes -6.00976162 42 More
GO:0099537 trans-synaptic signaling GO Biological Processes -5.17038357 38 More
GO:0120161 regulation of cold-induced thermogenesis GO Biological Processes -19.1025541 38 More
GO:0120162 positive regulation of cold-induced thermogenesis GO Biological Processes -19.5569802 32 More
GO:0140352 export from cell GO Biological Processes -8.94733589 48 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1901343 negative regulation of vasculature development GO Biological Processes -32.5354692 52 More
GO:1901888 regulation of cell junction assembly GO Biological Processes -8.71146171 30 More
GO:1901890 positive regulation of cell junction assembly GO Biological Processes -5.75086352 17 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1903524 positive regulation of blood circulation GO Biological Processes -11.6803256 16 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903531 negative regulation of secretion by cell GO Biological Processes -17.4034654 36 More
GO:1903532 positive regulation of secretion by cell GO Biological Processes -27.9542102 63 More
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -32.3948799 57 More
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -18.2876323 28 More
GO:1903672 positive regulation of sprouting angiogenesis GO Biological Processes -8.11481650 11 More
GO:1903828 negative regulation of protein localization GO Biological Processes -8.86943289 30 More
GO:1903829 positive regulation of protein localization GO Biological Processes -12.9651258 57 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
GO:1904950 negative regulation of establishment of protein localization GO Biological Processes -11.4813166 27 More
GO:1904951 positive regulation of establishment of protein localization GO Biological Processes -13.0308630 46 More
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling GO Biological Processes -7.80587066 38 More
GO:1905564 positive regulation of vascular endothelial cell proliferation GO Biological Processes -12.8410298 14 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:2000181 negative regulation of blood vessel morphogenesis GO Biological Processes -32.6997315 52 More
GO:2000831 regulation of steroid hormone secretion GO Biological Processes -6.94577761 6 More
GO:2000846 regulation of corticosteroid hormone secretion GO Biological Processes -5.83914312 5 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
Drug-Gene interaction
view
Related drugs: 12 records
Drug name Interaction type Source PMID View
anakinra NCI 16959954 view
celecoxib NCI 18414388 view
epinephrine NCI 16527847 view
etanercept NCI 18400355 view
insulin NCI 17449920 view
macimorelin TdgClinicalTrial view
pioglitazone NCI 16682836 view
psyllium seed husks NCI 17998014 view
raloxifene NCI 18164562 view
relamorelin TTD view
risperidone NCI 18480685 view
rofecoxib NCI 16868036 view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
appetite-regulating hormone proteomics excellent predictor type 2 diabetes mellitus[prognosis (bad)] ST elevation myocardial infarction Barbarash O et al. Arch Med Sci. 2017
appetite-regulating hormone proteomics insulin resistance[prognosis (bad)] acute ST elevation myocardial infarction Gruzdeva O et al. BMC Cardiovasc Disord. 2014
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